Longitudinal transcriptomic profiles associated with onset and remission of adolescent depression

This study identifies distinct transcriptomic signatures underlying divergent trajectories of adolescent depression. A dynamic regulation of inflammatory responses appears to support remission, while progressive impairment of immune, metabolic, GABAergic, glutamatergic and serotoninergic pathways characterizes both persistence of MDD and the transition from high-risk status to disorder onset. These findings highlight potential biological targets for prevention and stratified interventions in adolescent depression.