Circulating exhausted CD8+ effector memory cells differentiate immune checkpoint inhibitor-induced liver injury from other acute immune-mediated liver injuries

20260 citationsJournal Articlegold Open Access

Authors

Stuart Astbury · Nottingham University Hospitals NHS Trust

Edmond Atallah · Nottingham University Hospitals NHS Trust

Jane I Grove · Nottingham University Hospitals NHS Trust

Amber Bozward · University Hospitals Birmingham NHS Foundation Trust

Scott P. Davies · University Hospitals Birmingham NHS Foundation Trust

Mark Sheehan · Pfizer (United States)

Steven W. Kumpf

Abstract

We have shown that circulating CD8<sup>+</sup> T cells provide a potential biomarker to distinguish ChILI from DILI and AIH, and highlight different mechanistic pathways between ChILI and other immune-mediated liver injuries.

Topics & Keywords

Cancer Immunotherapy and Biomarkers Drug-Induced Hepatotoxicity and Protection CAR-T cell therapy research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal for ImmunoTherapy of Cancer

Volume 14, Issue 3, pp. e014178-e014178

DOI: 10.1136/jitc-2025-014178

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