Impact of a Cellular Host-Response Sepsis Diagnostic on Clinical Decision Making in the Emergency Department: A Vignette-Based Study

Objectives: Sepsis is a complex pathogen-host interaction that traditional laboratories do not easily detect.A test that rapidly assesses immune dysregulation could improve early diagnosis and clinical decision making.This study evaluates ease of application of a new host-response sepsis diagnostic test (IntelliSep; Cytovale, Inc) and its ability to affect decision making, risk stratification, and diagnostic efficacy in the emergency department (ED).Methods: This was a case vignette-based, randomized, multisite decision-impact study.We conducted the study with ED clinicians from 3 health care institutions,