Establishment of Gemcitabine-resistant Mouse Pancreatic Ductal Adenocarcinoma Cell Line and Possible Therapeutic Agents

20260 citationsJournal Articlehybrid Open Access

Authors

Kumiko Miyashita · Kobe University

Kimihiro Yamashita · Kobe University

MAKOTO MIYOSHI · Kobe University

Takaaki Nishiyama · Kobe University

Yuki Ise · Kobe University

SHUN OHSAKA · Kobe University

K. Shimizu · Kobe Medical Center

Abstract

We established a novel GEM-resistant mPDAC model and identified MAOB as a promising therapeutic target. These findings provide a rationale for targeting MAOB-driven survival signals to overcome chemoresistance in refractory pancreatic cancer.

Topics & Keywords

Pancreatic and Hepatic Oncology Research Cancer, Stress, Anesthesia, and Immune Response Pancreatic function and diabetes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Anticancer Research

Volume 46, Issue 4, pp. 1819-1831

DOI: 10.21873/anticanres.18076

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