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PBPK Modelling of PROTACs: Learnings from ARV-110 as a Case Example

20260 citationsJournal Article

Authors

Farzaneh Salem · Age UK

Ali Tabatabaeian Nimavardi · Simcyp (United Kingdom)

Abhishek Srivastava · AstraZeneca (Singapore)

Katharina Krollik · Merck (Germany)

Andreas Reichel · Bayer (Germany)

David Cebrian · Drug Discovery Laboratory (Norway)

Kunal S. Taskar ·

Topics & Keywords

Protein Degradation and Inhibitors Chromatin Remodeling and Cancer Receptor Mechanisms and Signaling

Publication Details

Published in: The AAPS Journal

Volume 28, Issue 3

DOI: 10.1208/s12248-026-01231-0

Field-Weighted Citation Impact: 0.00

James W. T. Yates · Age UK

Caroline Rynn · Roche (United Kingdom)

Heide Marika Duevel · Merck (Germany)

PBPK Modelling of PROTACs: Learnings from ARV-110 as a Case Example | Researchclopedia