Comparative Analysis of Four Matrix Dilution Methods for Eliminating <scp>IgM</scp> Paraprotein Interference in Prealbumin and Uric Acid Assays: Based on Two Case Reports

Effective elimination of IgM paraprotein interference requires assay-specific pretreatment strategies. PEG-based dilution is optimal for PA immunoturbidimetric assays, while osmotic modulation with hypertonic saline is most effective for UA measurement. Deionized water dilution provides a practical, broadly applicable alternative. These simple protocols are suitable for routine clinical laboratory implementation.