Effects of acute fluctuations of extracellular Zinc on network activity of human iPSC-derived neurons; impact of NMDA Receptor and L-Type Calcium Channel Activation

Acute fluctuations in extracellular Zn²⁺can impact both phasic neuronal connectivity and at higher levels can lead to neuronal toxicity in human neurons. The data may have relevance for, and explain in part, the known links between Zn²⁺ and conditions such as schizophrenia, where the malfunctioning synapse is increasingly the focus of pathology, and neurological conditions associated with neurotoxicity.