Regional system for automated validation of microbiological reports and antimicrobial resistance monitoring: the experience of the Yamalo-Nenets Autonomous Okrug

Objective. Creation and evaluation of the effectiveness of an integrated system for automatic validation of microbiological reports and monitoring of antimicrobial resistance (AMR) on real time at the regional level within the Yamalo-Nenets Autonomous Okrug (YNAO). Materials and Methods. The prospective study was conducted from October 2023 to June 2025, based on the Medical Information and Analytical Center and five largest hospitals in the YNAO. The study design included a comparative analysis of AMR monitoring status before and after the implementation of the digital platform. The objects of the study were data from 11728 microbiological reports, 12216 isolates, and the results of a survey conducted among 53 doctors. The period after implementation lasted 12 months, from June 2024 to June 2025. The primary endpoint was a comprehensive evaluation of the system based on criteria, including automatic validation level, coverage of healthcare facilities, data accessibility, and analytical capabilities. Methods for assessment included analyzing the operational data of the platform, conducting a structured survey among doctors, and assessing cost-effectiveness using an approved methodology. Results. After implementation, the system achieved 100% coverage of the planned healthcare facilities (5 hospitals). A total of 11728 cases were processed, of which 77,2% (9057⁄11728) generated expert reports by the system (median – 3 reports per analysis). In 19,3% of cases (2267⁄11728), high- and medium-risk reports were identified, indicating potential therapy errors. A survey of 53 doctors found that 66% (35⁄53) do not experience difficulties reading new opinion forms, and 87% (46⁄53) regularly read system-generated comments, with 96% (51⁄53) finding them useful for antibiotic selection. The economic impact of the system amounts to 110 million rubles per year, with potential annual prevention of up to 14 deaths. Conclusions. The introduction of the system for AMR monitoring and automated validation of microbiological reports in the Yamalo-Nenets Autonomous District has led to the standardization of microbiological diagnostics, increased safety of antimicrobial treatment, and the provision of upto-date epidemiological data in real-time. The system has shown significant clinical and economic benefits, demonstrating the feasibility of replicating it in other regions of the Russian Federation.