Atg2 coordinates microbial metabolite signaling and epigenetic remodeling to maintain intestinal lipid homeostasis in Drosophila

Our work establishes Atg2 as a guardian of microbiota-derived metabolite signaling, demonstrating that autophagy constrains microbial byproducts to prevent acetyl-CoA-mediated epigenetic hijacking of metabolic and immune networks. These findings reveal protein acetylation as a convergent regulator linking commensal ecology to host physiology, suggesting metabolite-centric therapies for dysbiosis-associated disorders. Video Abstract.