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Aim: Among the severe medical conditions that have a detrimental effect on patients' general quality of life are gynecological cancers. These patients may experience issues, including sleep difficulties and dietary inadequacies, as a result of the disease itself as well as the treatment procedure. In this regard, it is essential to investigate how enteral formula supplementation affects the sleep quality of these patients to establish comprehensive care strategies that optimize their overall well-being. This study aimed to evaluate the effect of enteral nutrition support on sleep quality in patients diagnosed with gynecological malignancies and to offer new perspectives on holistic approaches to cancer care.Materials and Methods: A prospective study was designed between 2023 and 2025 in the Department of Obstetrics and Gynecology at Selçuk University Faculty of Medicine. Two groups were formed: one with and one without formula supplementation. Patients were evaluated using the Pittsburgh Sleep Quality Index (PSQI).The period during which they received formula was taken into account. The groups were evaluated primarily in terms of demographics, diagnosis, and surgical method.Results: In the group receiving enteral nutrition support, the mean preoperative PSQI score decreased from 7.10 ± 3.99 to 5.52 ± 4.33 on the 14th postoperative day, showing a significant improvement in sleep quality (p < 0.05). In the group not receiving enteral nutrition support, although the preoperative PSQI score decreased from 8.10 ± 4.22 to 6.45 ± 3.80 in the postoperative period, this change was not statistically significant (p > 0.05). In the intergroup comparison, postoperative PSQI scores were found to be lower in the group receiving enteral nutrition, but the difference did not reach the level of statistical significance (p > 0.05).Conclusion: The importance of sleep in evaluating the living standards of patients with malignant diseases is evident; therefore, individual support that increases sleep quality is considered to be of great importance.