Search for a command to run...
Background: Psoriasis is a chronic immune-mediated inflammatory disease associated with systemic comorbidities. Psoriatic arthritis (PsA) represents a more extensive disease phenotype and may be associated with a higher burden of metabolic comorbidities. Objective: To compare the prevalence of metabolic comorbidities between patients with psoriasis with and without psoriatic arthritis. Methods: A retrospective observational study was conducted including 548 patients with clinically confirmed psoriasis from multiple dermatologic centers in the Dominican Republic. Patients were categorized according to the presence or absence of psoriatic arthritis. Sociodemographic and clinical data were obtained from medical records. Metabolic comorbidities analyzed included obesity, hypertension, diabetes mellitus, and smoking status. Comparisons between groups were performed using chi-square tests. Variables with statistical significance in bivariate analysis were further evaluated using multivariable logistic regression to identify factors independently associated with psoriatic arthritis. Statistical significance was defined as p < 0.05. Results: A total of 548 patients were included, of whom 18.6% had psoriatic arthritis. Patients with PsA demonstrated a higher prevalence of obesity (41.2% vs 29.6%, p = 0.009), hypertension (45.7% vs 33.8%, p = 0.014), and diabetes mellitus (30.4% vs 21.7%, p = 0.038) compared with patients without PsA. Smoking was more frequent in the PsA group (27.5% vs 20.9%), although this difference did not reach statistical significance (p = 0.081). In multivariable logistic regression analysis, obesity (OR 1.84, 95% CI 1.18–2.87, p = 0.006) and hypertension (OR 1.52, 95% CI 1.01–2.29, p = 0.044) remained independently associated with psoriatic arthritis, while diabetes mellitus and smoking were not independently associated after adjustment. Conclusion: Patients with psoriatic arthritis exhibit a higher prevalence of metabolic comorbidities compared with those with psoriasis alone. These findings support the concept of psoriatic arthritis as a more systemic disease phenotype and highlight the importance of comprehensive metabolic evaluation in patients with psoriatic disease.