Search for a command to run...
Background: Psoriasis is a chronic inflammatory disease with heterogeneous clinical manifestations. Sex-related differences may influence disease expression, including joint involvement and associated comorbidities. Objective: To evaluate sex differences in clinical characteristics among patients with psoriasis. Methods: A retrospective observational study was conducted including 548 patients with clinically confirmed psoriasis from dermatologic centers in the Dominican Republic. Patients were stratified by sex. Clinical variables analyzed included psoriatic arthritis, obesity, hypertension, and diabetes mellitus. Comparisons between males and females were performed using chi-square tests, and a pvalue < 0.05 was considered statistically significant. Results: Male patients demonstrated a higher prevalence of psoriatic arthritis compared with females (20.5% vs 16.1%, p = 0.048). In contrast, obesity was significantly more frequent among female patients (36.4% vs 28.9%, p = 0.031). No statistically significant differences were observed between sexes in the prevalence of hypertension (38.7% vs 32.6%, p = 0.072) or diabetes mellitus (24.7% vs 21.6%, p = 0.215). Male patients demonstrated a higher prevalence of psoriatic arthritis compared with females (20.5% vs 16.1%, p = 0.048). In contrast, obesity was significantly more frequent among female patients (36.4% vs 28.9%, p = 0.031). No statistically significant differences were observed between sexes in the prevalence of hypertension (38.7% vs 32.6%, p = 0.072) or diabetes mellitus (24.7% vs 21.6%, p = 0.215). Conclusions: Significant sex-related differences were observed in the clinical profile of patients with psoriasis, with male patients demonstrating a higher prevalence of psoriatic arthritis and female patients exhibiting a greater burden of obesity. These findings suggest the presence of distinct sex-specific disease patterns, where joint involvement may be more prominent in males, while metabolic factors such as obesity may play a greater role in females. This divergence could reflect underlying biological, hormonal, or behavioral differences influencing disease expression. From a clinical perspective, these results highlight the importance of incorporating sexspecific considerations into the evaluation of psoriatic disease. In particular, heightened vigilance for early signs of joint involvement in male patients and targeted metabolic assessment in female patients may contribute to more timely diagnosis and comprehensive management. Further studies are needed to clarify the mechanisms underlying these differences and to determine their impact on long-term outcomes.