Endothelial tPA-dependent recruitment of microglia to vessels protects the blood-brain barrier after stroke

20260 citationsJournal Articlegold Open Access

Authors

Abstract

Collectively, these findings indicate that endothelial tPA promotes microglial recruitment to blood vessels and plays a protective role in preserving BBB integrity after ischemic stroke.

Topics & Keywords

Neuroinflammation and Neurodegeneration Mechanisms Barrier Structure and Function Studies Protease and Inhibitor Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Fluids and Barriers of the CNS

DOI: 10.1186/s12987-026-00801-w

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