Research based on serine metabolism indicates mesenchymal stem cells alleviate psoriasis by regulating the PSPH-PINK1-Parkin-NLRP3 pathway in HaCaT

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Authors

Qing Lin · Chinese Academy of Medical Sciences & Peking Union Medical College

Yunfei Ji · State Grid Corporation of China (China)

Bin Yang · Chinese Academy of Medical Sciences & Peking Union Medical College

Rongjia Zhu · State Grid Corporation of China (China)

Ping Song · Chinese Academy of Medical Sciences & Peking Union Medical College

Robert chunhua Zhao · Chinese Academy of Medical Sciences & Peking Union Medical College

Abstract

The results of this study indicated that MSCs can alleviate IMQ-induced psoriasiform dermatitis in mice by upregulating serine metabolism. The key serine metabolism enzyme PSPH may enhance PINK1/Parkin-mediated mitochondrial autophagy in psoriatic HaCaT and inhibit NLRP3 inflammasome activation in HaCaT cells, thereby alleviating skin inflammatory responses and suppressing skin p roliferation in psoriatic mice.

Topics & Keywords

Psoriasis: Treatment and Pathogenesis Mesenchymal stem cell research Inflammasome and immune disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Stem Cell Research & Therapy

DOI: 10.1186/s13287-026-04964-z

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