Methodological Challenges of Emulating a Target Trial to Assess Effectiveness of Timing of <scp>PCSK9</scp> Inhibitor Treatment Initiation Post Myocardial Infarction

The clone-censor-weight method is a promising approach that allows researchers to answer questions about the effect of treatment policies. But practical guidance is needed to address problems that arise from small, highly imbalanced groups, which is common with most newly introduced treatments.