Long-term impacts of HPV vaccination strategies on HPV related Cancer burden among Singaporean female population: A prospective simulation using proportional multistate lifetables

A gradual catch-up HPV vaccination program targeting cohorts aged 17 years and above can substantially reduce the future burden of cervical and oropharyngeal cancers in Singapore. A hypothetical HPV Eradication scenario represents the upper bound of achievable benefit, and the catch-up program achieves approximately 89% of this maximum potential gain. These findings strongly support Singapore's ongoing national HPV vaccination strategy.