NANO-DIAMONDS: A MODERN APPROACH TO CREATING EFFECTIVE TOPICAL DRUGS

The problem of bacterial resistance to antibiotics is one of the main threats to the health of the population at the present time. Nanoparticles have great potential for the treatment of diseases such as oncology, cardiovascular pathologies, and infectious and inflammatory processes. The use of nanoparticles for targeted delivery of active pharmaceutical substances is being actively investigated. Understanding how nanoparticles interact with the skin is critically important for the development of topical dosage forms, for example, for delivery systems where nanoparticles slowly release a drug. Among various nanomaterials, nanodiamonds stand out as promising due to their ability to control the release of active pharmaceutical substances. Numerous studies have been conducted to assess the safety of nanodiamonds both in laboratory conditions (in vitro) and in living organisms (in vivo). Nanodiamonds demonstrate activity against bacteria, fungi and viruses, which makes them valuable for the creation of external preparations. Due to their ability to absorb and disperse ultraviolet radiation, nanoparticles can serve as components of sunscreens, both cosmetic and therapeutic. Their ability to penetrate into tissues makes them promising for the delivery of active substances through the skin. It is assumed that modification of the surface of nanoparticles will allow controlling their distribution in the skin, directing them to certain areas and regulating the release of drugs upon contact with skin cells and structures. In this regard, the development of new external dosage forms and delivery systems based on nanodiamonds, including in combination with other drugs, is an urgent task aimed at improving public health and improving the quality of medical care.