Mpox: An Emerging Undetected Public Health Threat

The emergence of viral infectious diseases is an enormous challenge for global public health systems to protect their communities. By March 5, 2024, there were greater than 94,297 cases of Mpox infections, including 198 deaths in non-endemic parts of the globe. As of this writing, Mpox has caused greater than 100,000 cases in 122 countries. The number of new infections continues to rise and currently represents 115 countries where Mpox was not previously observed (CDC, December 2025). This article provides an overview of the monkeypox virus, as the virus may be circulating not only undetected in communities across the Unted States, but globally.