Psorijaza i parodontitis: zajednička imunopatogeneza, molekularni upalni mehanizmi i kliničke implikacije

Psoriasis is a chronic, autoimmune, genetically determined and frequently re- curring skin disease characterized by specific clinical features in the form of er- ythematous squamous plaques. The development of psoriasis is influenced by genetic and environmental factors, as well as a complex inflammatory cascade. To this day, there is no precise information identifying the main trigger of the in- flammation and formation of psoriatic plaques. In patients suffering from psori- asis, an increased prevalence of periodontitis has been observed. Severe forms 3 4 of periodontitis are the 6th most common chronic disease, with a prevalence of 11.2% and affecting more than 800 million people worldwide. The chronic inflammation and immune mechanisms involved in the development of this dis- ease remain a subject of ongoing research and the search for key therapeutic options. In this review paper, we explored the relationship between the chronic inflammatory immune processes underlying psoriasis and periodontitis, as well as the potential frequency and possibility of triggering the onset of a multisys- tem disease, such as psoriasis, in patients with periodontal disease.