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Abstract The skin serves as the largest organ of the human body and acts as a primary protective barrier against environmental factors. However, this barrier property also limits the effective penetration of therapeutic agents, posing significant challenges for topical drug delivery. Conventional dermatological formulations such as creams, ointments, and gels often exhibit poor drug permeation and limited therapeutic efficiency. In recent years, nanotechnology-based delivery systems have emerged as promising alternatives to overcome these limitations. Among these, polymeric micelles have gained considerable attention due to their nanoscale size, high drug- loading capacity, and ability to enhance drug solubility and stability.Polymeric micelles are self- assembled nanostructures formed by amphiphilic block copolymers that organize into a hydrophobic core surrounded by a hydrophilic shell. These structures enable the encapsulation of poorly soluble drugs and facilitate improved drug penetration through the skin barrier. Their small size allows efficient interaction with skin layers, enhancing dermal drug delivery and localized therapeutic action. Moreover, polymeric micelles offer controlled drug release, improved bioavailability, and reduced systemic toxicity. This research highlights the structural characteristics, preparation techniques, characterization methods, and mechanisms involved in the cutaneous delivery of drugs using polymeric micelles. Furthermore, their applications in treating dermatological disorders such as psoriasis, acne, fungal infections, and skin cancer are discussed. The article also addresses current limitations, challenges, and future perspectives associated with polymeric micelle-based dermal drug delivery systems. Cutaneous drug delivery remains a major challenge due to the barrier function of the skin, particularly the highly organized structure of the stratum corneum, which restricts the penetration of many therapeutic agents. Conventional topical formulations such as creams, ointments, and gels often demonstrate limited drug solubility, poor permeation, and suboptimal therapeutic efficacy. In recent years, nanotechnology-based delivery systems have emerged as promising strategies to overcome these limitations. Among them, polymeric micelles have gained considerable attention as efficient nanocarriers for cutaneous drug delivery. Polymeric micelles are self-assembled nanosized structures formed from amphiphilic block copolymers, typically ranging from 10 to 100 nm in diameter, consisting of a hydrophobic core and a hydrophilic shell. This unique architecture enables the encapsulation of poorly water-soluble drugs within the hydrophobic core while maintaining stability in aqueous environments through the hydrophilic corona. The present research also discusses the structural characteristics, preparation methods, physicochemical properties, and mechanisms of skin penetration associated with polymeric micelle systems. Particular emphasis is placed on their ability to enhance drug solubility, improve skin permeation, provide controlled drug release, and minimize systemic exposure. Furthermore, recent advancements in polymeric micelle-based formulations for the treatment of dermatological disorders such as psoriasis, acne, fungal infections, eczema, and skin cancer are critically analyzed. The review also highlights key challenges including micelle stability, scalability, and regulatory considerations that must be addressed for successful clinical translation. Overall, polymeric micelles represent a promising nanotechnological platform capable of significantly improving topical drug delivery and therapeutic outcomes in both normal skin and various dermatological conditions. Keywords: Polymeric micelles, nanocarriers, dermatological drug delivery, skin barrier, topical drug delivery, nanotechnology