Integrating chronic inflammation and hypoxia

20260 citationsJournal Articlegreen Open Access

Authors

David Lukanović · Ljubljana University Medical Centre

Erik Škof · Institute of Oncology Ljubljana

Borut Kobal · Ljubljana University Medical Centre

Katarina Černe · University of Ljubljana

Abstract

High-grade serous ovarian carcinoma (HGSOC) is marked by late diagnosis and chemoresistance, partly driven by chronic inflammation and hypoxia in the tumor microenvironment. Hypoxia-inducible factor 1-alpha (HIF-1a) is a key regulator of these processes

Topics & Keywords

Cancer, Hypoxia, and Metabolism Immune cells in cancer Cancer, Stress, Anesthesia, and Immune Response

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: DiRROS repository (University of Maribor)

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