Advances in research on the mechanisms of anti-inflammation of silybin: a review

Silybin, as the main active component of milk thistle, has attracted significant attention in recent medical research due to its remarkable anti-inflammatory effect. Inflammatory responses are an important mechanism in the pathogenesis of various clinical diseases, and controlling inflammation is crucial for the prevention and treatment of diseases. Existing studies have shown that silybin can regulate the release of inflammation-related cell factors, inhibit oxidative stress responses, modulate apoptosis, and immune function, thereby exerting multi-target and multi-pathway anti-inflammatory effects. This article systematically reviews the anti-inflammatory mechanisms of silybin in various clinical diseases, including neurological diseases, respiratory diseases, and digestive system diseases, and analyzes the latest progress in its mechanisms of action, aiming to provide a theoretical basis for its clinical applications and promote the development and application of silybin as a novel anti-inflammatory drug.