Adverse events in small dogs treated with a single dose of vinblastine

Vinblastine administered at a dosage of 2.0 mg/m2 in small dogs with malignant tumors resulted in gastrointestinal toxicity within clinically acceptable limits, but close monitoring for neutropenia is warranted. These findings suggest that dose escalation of VBL, as reported in larger dogs, may not be feasible in smaller dogs.