Efficacy and Safety of Rapid Dose Escalation of Methotrexate in Rheumatoid Arthritis (Results of the Multicenter METEOR Study)

With high RA activity, the tactics of starting therapy with sc MTX at a dose of 15 mg per week and a rapid escalation of its dose of 2.5 mg weekly to 22.5-25 mg/week, allows achieving therapy goals by 3 months in 17.8% of patients, and by 6 months in 64.5%, to quickly improve the QOL, reduce the level of pain, reduce the dose of GC by 3 months of therapy or completely cancel them, and reduce the need for NSAIDs by 7 times with an acceptable level of therapy safety.