Development and justification of the use of the drug ATP in the treatment of periodontitis (experimental study)

The aim is to study the clinical efficacy of topical application of adenosine triphosphate (ATP) disodium salt solution in the treatment of experimental periodontitis in laboratory animals. Materials and methods. A model of periapical periodontitis was experimentally created in 30 Wistar rats. The animals were divided into 3 equal groups based on the treatment method: I — no treatment (control); II — traditional treatment of periodontitis according to clinical recommendations; III — treatment with ATP. On days 7, 14, and 21 of treatment, the periodontium with adjacent fragments of the tooth and maxillary alveolar process was examined. Immunohistochemical examination was performed using monoclonal antibodies (MAb) to identify all leukocytes, neutrophilic leukocytes, T-lymphocytes, B-lymphocytes, macrophages, and fibroblasts. On histological sections, the area of unchanged periodontal tissue, blood vessels, periodontal tissues with diffuse inflammatory cellular infiltration, foci of lysis and destruction, and leukocyte-necrotic masses was measured. Conclusions. When using the ATP drug together with traditional treatment of an experimentally created model of periodontitis in rats, the clinical signs of inflammation in the periodontal tissue were eliminated and the general condition improved.