MR‐Guided Laser Interstitial Thermal Therapy for Recurrent Glioblastoma: A Case Report With Novel Insights Into Histopathological Changes and Immunological Responses

MR-guided laser interstitial thermal therapy (LITT) offers a minimally invasive option for recurrent glioblastoma, but human post-treatment tissue data are scarce. In this case report, post-LITT tissue exhibited distinct zonal changes, including central necrosis within the ablation zone and reduced tumour proliferation with increased CD8⁺ T-cell infiltration in the perilesional transition zone, suggesting that LITT may influence the local immune landscape in recurrent glioblastoma.