Profillin‐1 and Transgelin‐2: Actin Binding Proteins Expression in Early and Advanced Stages of Triple‐Negative Breast Cancer Receiving Neoadjuvant Chemotherapy

Aberrantly expression of actin binding proteins, PFN-1 and TAGLN-2 and tumor suppressor gene PTEN in pre and post-NAC patients in different tumor stages compared with healthy individuals can provide valuable prognostic information and may have potential as a therapeutic target. The observed interactions of PFN-1 with VASP and potential crosstalk with TAGLN-2 point toward their collective role in actin cytoskeleton regulation and tumorigenesis.