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The Intrinsic Response Sector (IRS) is developed as a constitutive spacetime-response framework in which additional gravitating curvature is sourced functionally by baryonic stress-energy, without introducing new propagating fields beyond the metric. In this manuscript, IRS is explicitly treated as a probe exploration of intrinsic spacetime mechanics: the central claim is not completion, but that a physically structured response law can be tested, refined, and rejected under cross-domain constraints. In its established domain, IRS retains strong galactic-scale performance across SPARC-175, including high BIC preference over two-parameter halo baselines and robust baryonic scaling consistency. The program is then extended with explicit cluster and cosmological closure gates. Cluster offset benchmarks, including Bullet Cluster, Abell 2744, and MACS J0416, are treated as quantitative constraints for the merger-simulation stage. Cosmological kernel diagnostics in FRW plus perturbation settings provide a sharp family-level discriminator: instantaneous kernels fail the frequency-separation test, whereas memory kernels satisfy the qualitative phase-separation criterion over the tested scales. The principal unresolved issue is cross-domain amplitude calibration, since galaxy-calibrated coupling levels remain below full CDM-equivalent recombination amplitude in the current implementation. This paper additionally draws on the Kit State Lifecycle (KSL) framework to characterize the information-theoretic structure of the pre-hadronic epoch and its transfer into the IRS cosmological source term. Terminology is made explicit: in boundary lifecycles, matter undergoes recrystallization, meaning return from a prior constituent regime, while in cosmology at the QCD crossover the relevant event is primordial crystallization or constituent birth, meaning first emergence rather than return. In both domains, KSL treats the kit state as a maximally scrambled source regime over constrained Hilbert-space degrees of freedom from which definite constituent outputs are selected under conservation-law constraints. This framing sharpens the tension with the LambdaCDM freeze-out narrative and provides a physically motivated pathway by which IRS retarded-kernel integration over pre-constituent history could close the approximately 27x amplitude gap between galaxy-calibrated coupling and recombination requirements. Appendix A develops the KSL-IRS source correspondence, Appendix B develops the broader IRS/KSL implications for outstanding quantum-gravity problem domains with explicit falsification gates, and Appendices C and D provide consolidated scaling tables and the full per-galaxy system table. IRS is advanced here as a high-constraint, falsifiable constitutive program with partial closures and decisive remaining tests, rather than a completed replacement model.