A Study of Glomerular Filtration and Kidney Volume in Patients with Alcohol Dependence

<b>Background: </b>The purpose of this study is to evaluate serum creatinine as a marker of estimated glomerular filtration rate (eGFR) in excessive alcohol use people, and to determine correlation between total kidney volume (TKV) and other relevant factors.  <br /> <b>Methods: </b>In this study, 95 people were examined 2025. We measured serum creatinine based GFR using the MDRD formula. Biochemical analysis and serum creatinine were evaluated using a fully automatic analyzer. TKV was determined by ellipsoid method using 2D sonographic transducer.<br /> <b>Result:</b> The mean subject age was 52±10, BMI 25±4 and male female ratio was 4:1. Mean arterial pressure was 108±14 mmHg, eGFR 90±19 ml/min/1.73m<sup>2</sup>.  Age, body mass index (BMI) and mean arterial pressure (MAP) were inversely correlated with eGFR (P<0.01) and no difference between male and female recipients. There is no statistically significant correlation between TKV and eGFR. BMI and arterial pressure was correlated with TKV (P<0.01). Mean eGFR and TKV was calculated into 4 groups of 10-year intervals, that eGFR was decreased significantly with age groups.  <br /> <b>Conclusion:</b> According to our research, one of the optimal methods for assessing kidney function is the creatinine-based calculation method, and long-term excessive alcohol consumption is a risk factor for chronic kidney disease (CKD).