The contribution of hormonal profile changes to determining cardiac prognosis in patients with stable coronary artery disease undergoing coronary revascularization

One of the factors influencing cardiac prognosis is changes in the balance of hormonal and metabolic parameters in the blood, particularly leptin, resistin, and testosterone, which are involved in chronic subclinical inflammation. The potential for using these markers in clinical practice formed the basis for the development of a prognostic model for determining cardiac prognosis after percutaneous coronary interventions with coronary artery stenting in patients with stable coronary artery disease, which was the aim of this study. It was shown that increased leptin and resistin levels, as well as decreased serum testosterone levels in patients with stable coronary artery disease, are associated with an increased risk of adverse cardiovascular outcomes within a year of coronary revascularization. In addition, an assessment was made of the influence of leptin, resistin, and testosterone levels on the outcome within 12 months after myocardial revascularization by constructing a prognostic model that allows assessing the likelihood of developing adverse cardiac events.