Case Report: Burkitt’s lymphoma with concurrent HIV, CMV encephalitis, and salmonella bacteremia

Burkitt’s lymphoma is a highly aggressive B-cell lymphoma associated with human immunodeficiency virus (HIV) infection. Despite antiretroviral therapy (ART), Burkitt’s lymphoma remains diagnostically and therapeutically challenging, especially with concurrent infections. We describe a 50-year-old man presenting with constitutional symptoms and Salmonella bacteremia, found to have newly diagnosed HIV, stage IV Burkitt’s lymphoma with central nervous system (CNS) and marrow involvement, and cytomegalovirus (CMV) viremia. His management required coordination of ART, chemotherapy, and infection treatment, complicated by CMV encephalitis and adherence barriers. This case highlights the challenges of managing overlapping malignancy and infection, emphasizing early HIV testing and patient-centered multidisciplinary care.