SalmonAct deciphers transcription factor regulatory activity in <i>Salmonella</i> transcriptomics

While modern high-throughput transcriptomics technologies provide effective ways of studying <i>Salmonella enterica</i>, the complexity of these datasets makes interpretation challenging. SalmonAct provides a new computational resource to connect gene expression changes with the activity of transcription factors, key regulators of bacterial adaptation and virulence. SalmonAct can help researchers progress from the analysis of gene expression profiles towards a clearer understanding of the regulatory programs driving the behavior of the pathogen. By integrating prior knowledge of transcription factor-target gene relationships, SalmonAct contributes to uncovering novel mechanisms of bacterial pathogenesis and supports the development of new approaches to combat <i>Salmonella</i> infections.