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The biosensor capable of detecting COVID-19 (SARS-CoV-2) viruses in the terahertz (THz) regime has the potential to revolutionize virus detection and diagnosis. One effective approach is the utilization of a new type of sensor called a multi-band metamaterial. These metamaterials are artificially engineered materials that exhibit properties not typically found in natural substances. They consist of sub-wavelength structures designed with precise electromagnetic properties. Multi-band metamaterial sensors can simultaneously detect multiple frequencies of THz radiation, increasing the likelihood of virus detection. These sensors offer several advantages, including high sensitivity, non-destructiveness, and the ability to accurately detect even small amounts of virus particles. Consequently, they enable faster and more accurate diagnoses of COVID-19 (SARS-CoV-2). In the THz regime, the biosensor employs a novel multi-band metamaterial resonator that incorporates a thin gold layer (35nm). The resonance frequency and parameter S11 (dB) of the sensor exhibit sensitivity to changes in the refractive index of the sample. This sensitivity allows for precise and reliable detection. The study demonstrated that our sensors exhibit minimal frequency offsets, compact electrical dimensions, high sensitivity, and a linear relationship between the sensor’s resonant frequency and refractive index, enhancing their effectiveness. The proposed structures have demonstrated the ability to detect COVID-19 viruses with an average sensitivity of 347.7GHz/RIU (2.154dB/RIU). This biosensor can differentiate between different types of COVID-19 viruses, further highlighting its potential in virus identification and classification.