Colorectal cancer in elderly patients: a literature review

In the context of global demographic aging, colorectal cancer is increasingly diagnosed in elderly and very old patients, representing a significant medical and social challenge, while the lack of data due to this group's underrepresentation in clinical trials results in variability in treatment approaches. This review aims to systematize current knowledge to formulate a personalized management strategy for such patients. Key aspects include the specific features of colorectal cancer in the elderly, the mandatory use of a Comprehensive Geriatric Assessment for risk stratification and treatment personalization, and the adaptation of surgical and pharmacological methods considering age-related changes in pharmacology and safety profiles. The most effective model is recognized as one that integrates the principles of geriatrics and oncology, optimizing the benefit-risk ratio and improving treatment outcomes and patients' quality of life.