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This paper aims to explore the relationship between academic entrepreneurship, new venture creation, and innovation, using a case study of a leading engineering college in Karnataka, India. The study employs a case study methodology to examine how the engineering college in a Tier 2 city in Karnataka has fostered academic entrepreneurship despite facing unique challenges. The case study reveals that SIT the college undertaken for study has established a supportive environment for academic entrepreneurship by going beyond traditional support for research. It provides infrastructure, mentorship, and financial aid to faculty members and others, without claiming ownership in the resulting ventures. Within three years of establishing its own incubation center, the college successfully converted two research ideas into ventures, with additional ventures in progress. The findings of this study have both theoretical and practical implications. Theoretically, it contributes to understanding the process of enhancing academic entrepreneurship. Practically, it provides insights into creating an ecosystem that can be replicated by other colleges seeking to foster academic entrepreneurship. This paper contributes to the literature by offering a detailed exploration of the relationship between academic entrepreneurship, new venture creation, and innovation within the context of SIT. It highlights the importance of providing comprehensive support to faculty members and others involved in academic entrepreneurship and offers a potential model for other colleges to emulate.