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Leptospirosis is a reemerging infection in tropical nations like India and one of the most neglected zoonotic diseases of public health concern globally. (Bharti et al., 2003; Levett, 2001). In order to regulate the infection and determine the reported disease rate, epidemiological and other vital data are limited for the least studied disease. This essay attempts to examine the importance of leptospirosis as sapronosis, which is as underappreciated as the sickness itself. The goal of the research evaluation was to reduce the disease's detrimental effects by gaining an epidemiological understanding of the infection. To comprehend the literature on important and understudied topics such epidemiology, transmission, diagnosis, therapy, and infection control, a combined review and analysis were conducted. Using the published data from PubMed, a systematic analysis was conducted to extract information on the reported circulating strains and research gaps in India (Gupta, Wilson and Ravindra, 2023).. In order to limit the spread of infection using the one health approach (OHA) (Krishnan, Balasubramanian and Kumar, 2024)., the paper comprehensively examines important inference areas of infection transmission, resolves lacunae in critically underappreciated regions of infection, and suggests solutions to control leptospiral infection. The article also discussed why and how India's "One health approach" is the most effective way to research and manage leptospirosis.