The predictive value of early systemic inflammatory response index (SIRI), serum β ₂ -microglobulin, and procalcitonin for acute kidney injury induced by wasp stings

Wasp stings can lead to acute kidney injury (AKI), and traditional renal biomarkers may be insufficient for early detection. In this study, the predictive value of the systemic inflammatory response index (SIRI), serum β₂-microglobulin (β₂-MG), and procalcitonin (PCT) levels measured at admission for predicting AKI in patients with wasp stings was evaluated. In this single-center retrospective study, 171 adult patients hospitalized for wasp stings between January 2021 and December 2024 were analyzed. The primary endpoint was AKI occurrence within seven days of admission. Compared with non-AKI group, patients who developed AKI were older, had more severe disease, sustained more stings, and had longer hospital stays (all <i>p</i> < 0.05). At admission, the SIRI, β₂-MG, and PCT levels were significantly elevated in the AKI group (all <i>p</i> < 0.001). Multivariate logistic regression revealed that the SIRI (OR = 1.69, 95% CI 1.24-2.31); β₂-MG (OR = 1.15, 95% CI 1.01-1.53); and PCT (OR = 1.95, 95% CI 1.07-3.58) were independent predictors of AKI. Receiver operating characteristic curve analysis revealed strong discriminative performance for AKI prediction (AUCs: 0.933, 0.886, and 0.859; all <i>p</i> < 0.001). Early assessment of the SIRI, β₂-MG, and PCT may facilitate timely risk stratification and support early clinical decision-making in patients with wasp stings.