Impact of sex on residual angina after percutaneous coronary interventions

Abstract Background Significant differences in the presentation of coronary artery disease (CAD) have been observed between women and men. The pullback pressure gradient (PPG) quantifies pathophysiological CAD patterns as focal or diffuse. Objectives This study investigated the influence of sex on residual angina stratified by PPG after percutaneous coronary intervention (PCI). Methods We performed a sub-analysis of the PPG Global, a multicenter, prospective, single-arm study. All patients had hemodynamically significant CAD (fractional flow reserve [FFR] ≤ 0.80) and underwent a manual FFR pullback to calculate PPG before PCI. Patient-reported outcomes were collected using the 7-item Seattle Angina Questionnaire (SAQ-7) at baseline and one-year follow-up. Results We included 814 patients (205 [25.2%] women and 609 [74.8%] men). Women were significantly older than men (70.2±10.2 years vs 67.2±10.0 years p< 0.001). Baseline FFR were comparable between sexes (0.68±0.13 vs. 0.66±0.12, p=0.098) but women had a more focal CAD compared to men (PPG 0.66 ± 0.15 vs. 0.63 ± 0.15, p=0.047). Post PCI-FFR was higher in women than men (0.88 ± 0.07 vs. 0.87 ± 0.07, p=0.041); however, angina at one year was more frequent in women (SAQ angina frequency score 94.4 ± 12.4 vs 96.1 ± 9.6, p=0.041). Conclusion Despite having a more focal CAD pattern and achieving higher post-PCI FFR, women report more residual angina than men at one-year follow-up.Graphical abstractFor image description, please refer to the figure legend and surrounding text. SAQ-7 at 12 month - Men vs. WomenFor image description, please refer to the figure legend and surrounding text.