Utility of Acute Vasodilator Challenge with Inhaled Nitric Oxide to Predict Pulmonary Hemodynamic Reversibility in Patients with Pulmonary Hypertension due to Left Heart Disease Referred for Heart Transplantation

Pulmonary hypertension due to left heart disease (PH-LHD) in heart transplantation (HTx) candidates is associated with increased post-transplant mortality. Although guidelines recommend acute vasodilator challenge (AVC) with nitroprusside or milrinone, the safety and utility of inhaled nitric oxide (iNO) for AVC in this setting remain unclear.