Unlocking Bactericidal Potential of Coenzyme Q ₁₀ through an Optimized Oral Nano-system Formulation Approach: <i>In-Vitro</i> Characterization and Antimicrobial evaluation.

This study shows that a rationally designed proliposomal system markedly improves Coenzyme Q₁₀ dissolution and revives its antimicrobial activity. To our knowledge, this is the first report to provide conclusive evidence of Coenzyme Q₁₀'s significantly augmented antibacterial efficacy via nano-encapsulation. The optimized formulation presents a highly promising and translatable strategy for combating infections caused by resistant Gram-negative bacteria, meriting further investigation in clinical settings.