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Dataset for -omics figure in the following manuscript: https://doi.org/10.1101/2025.05.16.654545 Abstract: Astrocyte functional heterogeneity within a given neuronal circuit remains largely undetermined, particularly their role at tripartite synapses. Here, we examine multiple functional characteristics of astrocytes distinguished by their specific spatial relation to inhibitory synapses made on distinct hippocampal CA1 pyramidal cell domains: astrocytes covering the peri-somatic area in stratum pyramidale (SP) receiving input from Parvalbumin interneurons, or the apical dendritic area in stratum radiatum (SR) innervated by inhibitory inputs from Somatostatin interneurons. SP and SR astrocytes exhibit differences in morphological polarization, syncytial architecture and input resistance. The two populations of astrocytes display different intrinsic Ca2+ signaling properties and transcriptional signatures, notably for regulation of cell growth and morphology, synaptic function and signaling. SP and SR astrocytes regulate inhibitory synapses exclusively in their own syncytial territory, and selectively mediate long-term depression at the respective inhibitory synapses through Ca2+- dependent modulation of post-synaptic targets. Overall, our findings reveal functional specialization of astrocytes in the hippocampus that regulate specific inhibitory synapses. Spatial transcriptomics multiplexed error-robust fluorescence in situ hybridization (MERFISH) data were analyzed from the Allen Brain Cell (ABC) Atlas hosted on the Allen Institute AWS S3 repository using a dataset and metadata comprising 500 genes in 4 million cells across a single adult male C57BL/6J mouse brain (data version 20230830, metadata version 20241115; https://alleninstitute.github.io/abc_atlas_access/descriptions/MERFISH-C57BL6J-638850.html). See: Z. Yao et al., A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain. Nature 624, 317-332 (2023).