Mapping ionized calcium levels and evaluating the outcome of prehospital calcium supplementation in acute trauma and hemorrhagic shock

This study demonstrates that while hypocalcemia occurs early and consistently in both models of trauma-hemorrhage, simple calcium repletion is insufficient to improve survival. The lack of additional benefit from calcium supplementation when combined with life-saving plasma suggests that the underlying pathophysiology is more complex than a simple calcium deficit. Future strategies must look beyond mere repletion, investigate other primary drivers of trauma-induced hypocalcemia, and optimize the dosing of calcium supplementation.