PROSPECTS OF COURSE PHOTODYNAMIC THERAPY IN PALLIATIVE STENTING IN PATIENTS WITH MALIGNANT TUMORS OF THE BILE DUCTS

Background. The frequency of successful stenting is analyzed in dynamics, and the possibilities of its improvement are analyzed with the help of a course of photodynamic therapy. Objective. The aim of the study was to present the possibilities of a photodynamic therapy in palliative stenting in patients with malignant tumors of the bile ducts. Materials and Methods. In a comparative retrospective study of the frequency of palliative stenting in patients with malignant tumors of the bile ducts, in the first stage, the dynamics of the number of hospitalized patients with mechanical jaundice, changes in the tactics of managing patients with mechanical jaundice of tumor genesis, the frequency of successfully performed palliative stenting of the common bile duct in the Altai Regional Hepatology Center based on the City Hospital No. 5 (Barnaul) and the surgical department of the Almaty Regional Multidisciplinary Clinic were analyzed. Results. When comparing the successful stenting in the Altai Regional Hepatology Center, which was 10% of the patients, and the surgical department of the Almaty Regional Multidisciplinary Clinic, where the frequency of successful stenting was 13.5%, no statistically significant differences were found. The introduction of course photodynamic therapy in patients with malignant tumors of the bile ducts made it possible to successfully stent the common bile duct in patients after the first course and then prevent recurrence of mechanical jaundice with repeated courses, including with an increase in the diameter of the stent. At the same time, no clinically significant complications were found after photodynamic therapy. Conclusion. Photodynamic therapy seems to be a promising method for treating patients with malignant tumors of the bile ducts, including not only in connection with an increase in life expectancy but also with an improvement in the quality of life due to the possibility of successful stenting, which in most cases is impossible due to late diagnosis of the tumor and the lack of technical capability due to locally advanced tumor growth.