Contrasting genetic effects within STAT4 define susceptibility and protection in <i>Leishmania guyanensis</i> Cutaneous Leishmaniasis

20260 citationsJournal Article

Authors

Lener Santos da Silva · Universidade Nilton Lins

Josué Lacerda de Souza · Universidade Nilton Lins

Lizandra Stephanny Fernandes Menescal · Universidade Federal do Amazonas

Júlia da Costa Torres · Universidade Federal do Amazonas

Ana Vitoria Sena Gouveia · Universidade Nilton Lins

Eryck Gabriel Rodrigues Silva · Universidade Federal do Amazonas

Micael Davi Lima de Oliveira

Abstract

Haplotypic variation at this locus significantly shapes host inflammatory responses, highlighting STAT4 as a key immunogenetic determinant of resistance to Leishmania infection.

Topics & Keywords

Research on Leishmaniasis Studies Trypanosoma species research and implications Cytokine Signaling Pathways and Interactions

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: The Journal of Infectious Diseases

DOI: 10.1093/infdis/jiag175

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