A Case Report of Behavioral Improvements in a Young Adult with Autism Spectrum Disorder Using Topically Applied Glutathione

Background: Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by impaired social communication and repetitive behaviors. Emerging evidence suggests oxidative stress and glutathione (GSH) imbalance may contribute to ASD pathophysiology.Case presentation: We report the case of a 22-year-old male diagnosed with ASD in childhood, presenting with persistent social communication difficulties and anxiety-related behaviors. The patient was administered transdermal glutathione using a cyclodextrin-based nano-carrier beginning in December 2023. Intervention and outcomes: Behavioral changes were reported within one week of initiation, including reduced anxiety, improved social engagement, and increased daily functioning. A temporary relapse occurred following discontinuation, with improvement upon re-initiation. Observations were primarily based on caregiver reports. Conclusion: This case suggests a potential association between transdermal glutathione and behavioral changes in ASD. However, due to the observational nature and lack of objective measures, further controlled studies are required.