Unanchored by two hits: IFNγ and mechanical stress synergize to undermine melanocyte adhesion and promote vitiligo

IFNγ and mechanical stress contribute to melanocyte detachment from the basement membrane via CTSL, FAK, and ITGβ1 regulation. These findings highlight the importance of melanocyte-basement membrane adhesion in vitiligo pathogenesis and offer insight into the Koebner phenomenon in disease progression.