Functional Brain Network Abnormalities and Aripiprazole's Modulatory Effects in Pediatric Tic Disorder

Pediatric TD patients present frontal dysfunction with compensatory adaptations in frontal-temporal connection and sensorimotor networks. Aripiprazole modulates global brain network connectivity and topology but not does not normalize frontal deficits, providing neurophysiological evidence for TD pathophysiology and aripiprazole's therapeutic mechanism.