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Introduction: Intermittent Claudication (IC), a painful manifestation of peripheral artery disease (PAD), is characterized by an imbalance between oxygen supply and demand in the lower limbs during physical activity and is associated with reduced walking capacity and health-related quality of life (HRQoL). Remote ischemic conditioning (RIC), a non-invasive intervention based on repeated cycles of limb ischemia and reperfusion, has been proposed to improve exercise tolerance in people with IC. However, the clinical effectiveness and safety of RIC in this population remain uncertain. Methods and Analysis: This protocol describes a systematic review and meta-analysis reported in accordance with the PRISMA-P statement. Electronic searches will be performed from 1986 to the most recent date prior to final analysis in MEDLINE, Embase, and CENTRAL. Eligible studies will include adults (≥18 years) with objectively confirmed PAD and IC, and classified as Rutherford categories 1–3 or Fontaine stages IIa–IIb. Participants with atypical claudication or with chronic limb-threatening ischemia will be excluded. Randomized controlled trials (RCTs) and non-randomized studies of interventions (NRSIs) will be included and synthesized separately. RIC will be compared with sham (placebo) interventions. Primary outcomes will include walking distance and time, and adverse events (AEs). Secondary outcomes will include physiological measures and HRQoL. Two reviewers will independently perform study selection and data extraction. Risk of bias (RoB) will be assessed using the Cochrane RoB 2 tool for RCTs and ROBINS-I for NRSIs. Certainty of evidence will be evaluated using the GRADE approach. Intervention characteristics will be described using the TIDieR checklist. Where appropriate, random-effects meta-analyses will use mean differences or standardized mean differences for continuous outcomes and risk ratios or odds ratio for dichotomous outcomes. Where meta-analysis is not feasible, results will be synthesized following SWiM guidance. Heterogeneity, subgroup, sensitivity, and exploratory analyses will be performed where data permit. Discussion: This review will synthesize evidence on the effectiveness and safety of RIC in people with IC to inform clinical decision-making and future research regarding the potential role of RIC as a rehabilitation intervention. Protocol registration: PROSPERO CRD42024566595. Funding: Publication costs are covered by Physioswiss (Swiss Association of Physiotherapy, Bern, Switzerland).