Olorofim in combination with azole antifungals: results from the Phase 2 salvage therapy study

20261 citationsJournal Articlehybrid Open Access

Authors

Johan Maertens · Rega Institute for Medical Research

Sharon C A Chen · New South Wales Department of Health

George R Thompson · University of California Davis Medical Center

Fariba M. Donovan · University of Arizona

Aaron Dane · Macclesfield College

Mike Birch · AstraZeneca (United Kingdom)

Corinne Pinder

Abstract

Although limited by small numbers of patients for individual fungi, this analysis did not demonstrate a pattern of reduced clinical efficacy or tolerability of olorofim when given in combination with either the mould-active azoles or with fluconazole.Trial registration number. NCT03583164.

Topics & Keywords

Antifungal resistance and susceptibility Peptidase Inhibition and Analysis Click Chemistry and Applications

Publication Details

Published in: Journal of Antimicrobial Chemotherapy

Volume 81, Issue 4

DOI: 10.1093/jac/dkag118

Field-Weighted Citation Impact: 32.19

Command Palette

Olorofim in combination with azole antifungals: results from the Phase 2 salvage therapy study

Authors

Abstract

Topics & Keywords

Publication Details