The Deubiquitinating Enzyme Otub2 Modulates Pancreatic Beta-Cells Function and Survival

Otub2 is a critical regulator of β-cell function, acting through modulation of NF-κB signaling and K⁺ channel-associated complexes. By deubiquitinating components such as Peg3 and Camk2d, Otub2 may protect β-cells from cytokine-induced apoptosis and sustain insulin secretory capacity. These findings position Otub2 as a potential therapeutic target for preserving β-cell function in diabetes.